Research Emphasis: The major focus of Dr. Mitchell's research is to investigate the molecular pathogenesis of herpes simplex virus (HSV) in transgenic mouse models. HSV is an important human pathogen and is closely related to a number of important pathogens of domestic animals. His major efforts have been concentrated on investigating the mechanism by which the virus remains latent in sensory ganglionic neurons and understanding the pathogenesis of HSV induced inflammation of ocular structures such as cornea and conjunctiva.
VPB 5554 Veterinary Virology
VPB 5576 Systemic Pathology I Autumn
VPB 6647 Diagnostic Pathology and Special Species Medicine
VPB 8432 Advanced Histopathology
Laura Schoenlaub, Alexandra Elliott, Daniel Freches, William Mitchell, and Guoquan Zhang (In Press) The role of B cells in host defense against primary Coxiella burnetii infection. Infect. Immun.
Ying Peng, Laura Schoenlaub, Alexandra Elliott, William J. Mitchell and Guoquan Zhang. 2014. Characterization of a Lipopolysaccharide-Targeted Monoclonal Antibody and Its Variable Fragments as Candidates for Prophylaxis against the Obligate Intracellular Bacterial Pathogen (Coxiella burnetii) Infect. Immun. 82(11):4530.
Zhang G, Peng Y, Schoenlaub L, Elliott A, Mitchell W, and Zhang Y. 2013. Formalin Inactivated Coxiella burnetii Phase I Vaccine-Induced Protection Depends on B Cells to Produce Protective IgM and IgG. Infect Immun.;81(6):2112-22
Peng Y, Zhang Y, Mitchell WJ, Zhang G. 2012. Development of a Lipopolysaccharide-Targeted Peptide Mimic Vaccine against Q Fever J Immunology, 2012, 189: 1–12.
Dumlao D S, Cunningham AM, Wax LE, Norris PC, Hanks JH, Halpin R, Lett KM, Blaho VA, Mitchell WJ, L.
Fritsche KL, Dennis EA, and Brown CR. 2012. Dietary fish oil substation alters the eicosanoid profile in ankle joints of mice during Lyme infection. J Nutrition. 142(8): 1582-1589.
Ritzman AM, Hughes-Hanks JM, Blaho VA, Wax LE, Mitchell WJ, Brown CR. The chemokine receptor CXCR2 ligand KC (CXCL1) mediates neutrophil recruitment and is critical for development of experimental Lyme arthritis and carditis. Infect Immun. 2010 Nov;78(11):4593-600.
Brown CR, Lai AY, Callen ST, Blaho VA, Hughes JM, Mitchell WJ. 2008. Adenoviral delivery of interleukin-10 fails to attenuate experimental Lyme disease. Infection and Immunity 76(12): 5500-5507.
Blaho, V A, Mitchell, WJ, Brown, CR. 2008. Arthritis Develops but fails to resolve during inhibition of cyclooxygenase 2 treatment in a murine model of lyme disease. Arthritis and Rheumatism. 58(5): 1485-1495.
Garcia-Tapia, D, Hassett, D, Mitchell, W, Johnson, G, Kleiboeker, s. 2007. West Nile virus encephalitis: sequential histopathological and immunological events in a murine model of infection. J Neurovirology 13:130-138.
Loiacono CM, Myers, R, and Mitchell WJ. 2004. The herpes simplex virus type 1 early gene (thymidine kinase) promoter is activated in neurons of brain but not trigeminal ganglia, of transgenic mice in the absence of viral proteins. Journal of Neurovirology 10: 116-122.
Loiacono CM, Taus NS, and Mitchell WJ. 2003. The herpes simplex virus type 1 immediate early gene ICP0 promoter is activated by viral reactivation stimuli in trigeminal ganglia neurons of transgenic mice. Journal of Neurovirology 9: 336-345
Loiacono, C.M., Myers, R., and Mitchell, W.J. (2002) Neurons differentially activate the herpes simplex virus type 1 immediate early gene ICP0 and ICP27 promoters in transgenic mice. J. Virol. 76: 2449-2459.
Taus, N.S. and Mitchell, W.J. (2001) The transgenic ICP4 promoter is activated in Schwann cells of trigeminal ganglia latently infected with herpes simplex virus type 1. J. Virol. 75: 10401-10408.
Chang, E., Galle, L., Maggs, D., Estes, D.M., and Mitchell, W.J. (2000) Pathogenesis of herpes simplex virus type 1-induced corneal inflammation in perforin-deficient mice. J. Virol. 74:11832-11840.