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George E. Rottinghaus
Clinical Professor, Biomedical Sciences
Chemist, VMDL

  • PhD, Iowa State University
Dr. Rottinghaus

Email: RottinghausG@missouri.edu

Research Emphasis: Dr. Rottinghaus's research focuses on using chromatographic techniques for developing new analytical methodology as well as isolation, purification of a number of natural products. Major interests have centered on fungal metabolites (mycotoxins), Tall Fescue alkaloids (ergovaline) and phyto and fungal estrogens. He has produced a number of important mycotoxins (T-2 toxin, diacetoxyscirpenol, aflatoxin, fumonisin, ochratoxin A, zearalenone and moniliformin) in large quantities from fungal culture for animal feeding studies in cattle, swine, chickens, turkeys, ducks, mink, catfish, and laboratory animals. Current research involves in vitro and in vivo examination of natural sorbents and fermentation products for decontaminating and remediation of animal feeds containing high levels of mycotoxins and developing rapid analytical methodology for the active components of medicinally important plants.

He is in charge of the Analytical Core Facility for the MU Center for Phytonutrient and Phytochemical Studies (MUCPPS) and is part of the research group that makes up the Fusarium/Poultry Research Laboratory at the University of Missouri.

Teaching: Veterinary Analytical Toxicology 

Selected Publications:

Simonyi A, Chen Z, Jiang J, Zong Y, Chuang DY, Gu Z, Lu CH, Fritsche KL, Greenlief CM, Rottinghaus GE, Thomas AL, Lubahn DB, Sun GY.2015. Inhibition of microglial activation by elderberry extracts and its phenolic components. Life Sci. 2015 Mar 2. pii: S0024-3205(15)00106-X. doi: 10.1016/j.lfs.2015.01.037. [Epub ahead of print]

Bovo F, Franco LT, Kobashigawa E, Rottinghaus GE, Ledoux DR, Oliveira CA. 2015. Efficacy of beer fermentation residue containing Saccharomyces cerevisiae cells for ameliorating aflatoxicosis in broilers1. Poult Sci.. pii: pev067. [Epub ahead of print]

Brownstein KJ, Rottinghaus GE, Knight M, Ito Y, Folk W. 2015. Isolation of Sutherlandioside B from Sutherlandia frutescens by Spiral Countercurrent Chromatography. J Liq Chromatogr Relat Technol. 2015;38(4):423-429.

Spiers DE, Wax LE, Eichen PA, Rottinghaus GE, Evans TJ, Keisler DH, and Ellersieck MR. 2012. Use of different levels of ground endophyte-infected tall fescue seed during heat stress to separate characteristics of fescue toxicosis. J. Anim. Sci. 90(10):3457-3467. PMID: 23038746

Evans TJ, Blodgett DJ, Rottinghaus GE: Fescue toxicosis. In Gupta, RC (ed): Veterinary Toxicology: Basic and Clinical Principles, 2nd edition. New York, Academic Press/Elsevier, Inc., 2012.

Landers BR, Brand LM, Kutz RE, Kobashigawa E, Ledoux DR, Rottinghaus GE, and Bermudez AJ. Effects of graded levels of melamine in young Pekin ducks. International Poultry Scientific Forum, Atlanta, Georgia January, 2010.

Murarolli RA, Moon D, Ledoux DR, Dreyer CL, Rottinghaus GE, and Bermudez AJ. Efficacy of different levels of adsorbents in ameliorating the toxic effects of aflatoxin B1 in broiler chicks. International Poultry Scientific Forum, Atlanta, Georgia January, 2010.

Brand LM, Murarolli RA,Kutz RE, Ledoux DR, Rottinghaus GE, and Bermudez AJ. Individual and combined toxicity of melamine (M) and cyanuric acid (CA) in male turkey poults fed dietary treatments from hatch to 21 days. International Poultry Scientific Forum, Atlanta, Georgia January, 2010.

Peterson CA, Schnell J, Kubas KL, and Rottinghaus GE. Effects of soy isoflavone consumption on bone structure and milk mineral concentration in a rat model of lactation-associated bone loss. European J Nutrition, 48(2):360-371, 2009.

Yarru LP, Settivari RS, Antoniou E, Ledoux DR, and Rottinghaus GE. Toxicological and gene expression analysis of the impact of aflatoxin B1 on hepatic function of male broiler chicks. Poultry Science 88:360-371, 2009.

Looper ML, Rorie RW, Person CN, Lester TD, Hallford DM, Aiken GE, Roberts CA, Rottinghaus GE, and Rosenkrans, CF, Jr. Influence of toxic endophyte-infected fescue on sperm characteristics and endocrine factors of yearling Brahman-influenced bulls. J Animal Science 87:1184-1191, 2009.

Qin W, Zhu W, Shi H, Hewett JE, Ruhlen RL, MacDonald RS, Rottinghaus GE, Chen YC, Sauter ER. Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women. Nutrition and Cancer 61(2):238-244, 2009.

Bozynski CC, Evans TJ, Kim DY, Johnson G, Hughes-Hanks JM, Mitchell WJ, Rottinghaus GE, Perry J, and Middleton JR. Copper toxicosis with hemolysis and hemoglobinuric nephrosis in three adult Boer goats. J Vet Diagn Invest 21(3): 395-400, 2009.

Roberts C, Kallenbach R, Hill N, Rottinghaus GE, and Evans TJ. Ergot alkaloid concentrations in tall fescue hay during production and storage. Crop Science, 49:1496-1502, 2009.

Kutz R, Sampson J, Pompeu LB, Ledoux DR, Spain J, Vazquez-Anon M, and Rottinghaus GE. Efficacy of Solis, Novasil Plus, and MTB-100 to reduce aflatoxin M1 levels in milk of early to mid lactation dairy cows fed aflatoxin B1. J Dairy Science 92:3959-3963, 2009.

Gowda NKS, Ledoux DR, Rottinghaus GE, Bermudez AJ, and Chen YC. Antioxidant efficacy of curcuminoids from turmeric (Curcuma longa) powder in broiler chicks fed diets containing aflatoxin1. British Journal of Nutrition 102:1629-1634, 2009.

Settivari RS, Evans TJ, Yarru LP, Eichen PA, Sutovsky P, Rottinghaus GE, Antoniou E, and Spiers DE. Effects of short-term heat stress on endophytic ergot alkaloid-induced alterations in rat hepatic gene expression. J Animal Sci 87(8):3142-3155, 2009.

Yarru LP, Settivari RS, Gowda NKS, Rottinghaus GE, Antoniou E, and Ledoux DR. Effects of turmeric (Curcuma longa), containing a known level of curcumin, on the expression of hepatic genes associated with biotransformation, antioxidant, and immune systems in broiler chicks. Poultry Science 88:2620-2627, 2009.

Buton A, Chen YC, Rottinghaus GE, and McMullen MD. Genetic variation at bx1 controls DIMBOA content in maize. Theor Appl Genet DOI: 10.1007/s00122-009-1192-1, 2009.

Tessari ENC, Kobashigawa E, Cardoso ALSP, Ledoux DR, Rottinghaus GE, and Oliveira CAF. Effects of aflatoxin B1 and fumonisin B1 on blood biochemical parameters in broilers. Toxins doi:3390/toxins 10x000x, 2009.

Dakovic A, Sekulic Z, Rottinghaus GE, Stojanovic A, Milicevic S, and Kragovic M. T-2 toxin adsorption by hectorite. J Serbian Chemical Soc 74(11):1283-1292, 2009.

 

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