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George E. Rottinghaus
Clinical Professor, Biomedical Sciences
Chemist, VMDL

  • PhD, Iowa State University
Dr. Rottinghaus

Email: RottinghausG@missouri.edu

Research Emphasis: Dr. Rottinghaus's research focuses on using chromatographic techniques for developing new analytical methodology as well as isolation, purification of a number of natural products. Major interests have centered on fungal metabolites (mycotoxins), Tall Fescue alkaloids (ergovaline) and phyto and fungal estrogens. He has produced a number of important mycotoxins (T-2 toxin, diacetoxyscirpenol, aflatoxin, fumonisin, ochratoxin A, zearalenone and moniliformin) in large quantities from fungal culture for animal feeding studies in cattle, swine, chickens, turkeys, ducks, mink, catfish, and laboratory animals. Current research involves in vitro and in vivo examination of natural sorbents and fermentation products for decontaminating and remediation of animal feeds containing high levels of mycotoxins and developing rapid analytical methodology for the active components of medicinally important plants.

He is in charge of the Analytical Core Facility for the MU Center for Phytonutrient and Phytochemical Studies (MUCPPS) and is part of the research group that makes up the Fusarium/Poultry Research Laboratory at the University of Missouri.

Teaching: Veterinary Analytical Toxicology 

Selected Publications:

Brownstein KJ, Knight M, Ito Y, Rottinghaus GE, Folk Wr. 2015. Isolation of the predominant cycloartane glycoside, sutherandioside B, from Sutherlandia frutescens (L.) R.Br. by spiral countercurrent chromatography. J Liquid Chrom & Related Technologies 38:4,423-429, DOI:10.1080/10826076.2014.9135182015.

Thomas AL, Byers PL, Gu S, Avery, Jr. JD, Kaps M, Datta A, Fernando L, Grossi P, and Rottinghaus GE. 2015. Occurrence of polyphenols, organic acids, and sugars among diverse Elderberry genotypes grown in three Missouri (USA) locations. 1 International Symposium on Elderberry, ISHS Acta Horticulturae 1061, ed. AL Thomas, 147-154.

Bovo F, Franco LT, Kobashigawa E, Rottinghaus GE, Ledoux DR and Oliveira CAF. 2015. Efficacy of beer fermentation residue containing Saccharromyces cerevisiae cells for ameliorating aflatoxicosis in broilers. Poultry Science (http://dxdoi.org/10.3382/ps/pev067).

Vekiru E, Fruhauf S, Rodrigues I, Krska R, Schatzmayr G, Ottner F, Ledoux DR, Rottinghaus GE and Bermudez AJ. 2015. In Vitro binding assessment and in vivo efficacy of several adsorbents to counteract the toxic effects of aflatoxin B1. World Mycotoxin Journal. ANIFEE-12-4049).

Lei W, Browning J Jr.1, Eichen PA, Lu C-H, Mossine VV, Rottinghaus GE, Folk WR, Sun GY, Lubahn DB, Fritsche KL. 2015. Immuno-stimulatory activity of a polysaccharide-enriched fraction of Sutherlandia frutescens occurs by way of the toll-like receptor-4 signaling pathway.  J  Ethnopharmacology 172:247-253.

Lei W, Browning J Jr., Eichen PA, Folk WR, Sun GY, Lubahn DB, Rottinghaus GE, Fritsche KL. 2015. Unveiling the anti-inflammatory activity of Sutherlandia frutescensin murine macrophages. International Immunopharmacology 29:254-262.

Campagnoolo FB, Franco LT, Rottinghaus GE, Kobashigawa E, Ledoux DR, Dakovic A, Oliveira CAF. 2015. In vitro evaluation of the ability of beer fermentation residue containing Saccharomyces cerevisiae to bind mycotoxins. Food Research International 77:643-648.

Borden K, Rottinghaus GE, Landers, B. R., Ledoux DR, Kobashigawa E., Corassin, C. H., and Oliviera, CAF. 2015. Evaluation of fumonisin exposure by determination of fumonisin B1 in human hair and in Brazilian corn products. Food Control 53:67-71.

Dos Anjos FR, Ledoux DR, Rottinghaus GE, Chimonyo M. 2015. Efficacy of Mozambican bentonite and diatomaceous earth in reducing the toxic effects of aflatoxins in chicks. World Mycotoxin Journal (online).

Simonyi A, Chen Z, Jiang J, Zong Y, Chuang DY, Gu Z, Lu C-H,  Fritsche KL, Greenlief MC, Rottinghaus GE , Thomas AL, Lubahn DB, and Sun GY. 2015.  Inhibition of microglial activation by elderberry extracts and its phenolic components. Life Sciences 128:30-38.

Bordin K, Rosim RE, Neef DV, Rottinghaus GE, and Oliveira CAF. 2014. Assessment of dietary intake of fumonisin B1 in São Paulo, Brazil. Food Chemistry 155:174-178.

Jiang J, Chuang DY, Zong Y, Patel J, Brownstein K, Lei W, Simonyi A, Gu Z, Cui J, Rottinghaus GE, Fritche KL, Lubahn DB, Folk WR, Sun GY et al. 2014. Sutherlandia frutescens ethanol extracts inhibit oxidative stress and inflammatory responses in neurons and microglial cells. PLOS ONE http://dx.plos.org/10.1371/journal.pone.0089748.

Roberts MD, Toedebusch RG, Wells KD, Company JM, Brown JD, Cruthirds CL, Heese AJ, Zhu C, Rottinghaus GE, Childs TE, and Boot FW. 2014. Nucleus accumbens neuronal maturation differences in young rats bred for low versus high voluntary running behavior. J Physiology 592.10:2119-2135.

Roberts CA, Davis DK, Looper ML, Kallenbach RL, Rottinghaus GE, and Hill NS. 2014. Ergot alkaloid concentrations in high- and low-moisture tall fescue silage. Crop Science 54:1887-1892.

Neeff DV, Ledoux DR, Rottinghaus GE, Bermudez AJ, Dakovic A, Murarolli RA, and Oliveira CAF. 2013. In vitro and in vivo efficacy of a hydrated sodium calcium aluminosilicate to bind and reduce aflatoxin residues in tissues of broiler chicks fed aflatoxin B1. Poultry Science 92:131-137.

Landers BR, Muraroli RA, Gelven RE, Brand LM, Kobashigawa EH, Ledoux DR, Bermudez AJ, and Rottinghaus GE. 2013. Individual and combined effects of melamine and cyanuric acid in young Pekin ducks. International Journal of Poultry Science 12(4):192-201.

Siloto EV, Oliveira EFA, Sartori JR, Fascina VB, Martins BAB, Ledoux DR, Rottinghaus GE, and Sartori DRS. 2013. Lipid metabolism of commercial layers fed diets containing aflatoxin, fumonisin, and a binder. Poultry Science 92: 2077-2083.

Patial V, Asrani RK,  Patil RD, Kumar S, Ledoux DR and Rottinghaus GE. 2013. Pathology of ochratoxin A-induced nephrotoxicity in Japanese quail and its protection by Sea Buckthorn (Hippophae rhamnoides L.).  Avian Diseases 57 (4):767-779, 2013.

Khan MA, Asrani RK, Iqbal A, Patil RD, Rottinghaus GE, and Ledoux DR. 2013. Fumonisin B1 and ochratoxin A nephrotoxicity in Japanese quail: An ultrastructural assessment. Comparative Clinical Pathology 22 (5):835-843.


 

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