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George E. Rottinghaus
Toxicology, Clinical Professor

  • PhD, Iowa State University
Dr. Rottinghaus

RottinghausG@missouri.edu

Research emphasis:
Dr. Rottinghaus's research focuses on using chromatographic techniques for developing new analytical methodology as well as isolation, purification of a number of natural products. Major interests have centered on fungal metabolites (mycotoxins), Tall Fescue alkaloids (ergovaline) and phyto and fungal estrogens. He has produced a number of important mycotoxins (T-2 toxin, diacetoxyscirpenol, aflatoxin, fumonisin, ochratoxin A, zearalenone and moniliformin) in large quantities from fungal culture for animal feeding studies in cattle, swine, chickens, turkeys, ducks, mink, catfish, and laboratory animals. Current research involves in vitro and in vivo examination of natural sorbents and fermentation products for decontaminating and remediation of animal feeds containing high levels of mycotoxins and developing rapid analytical methodology for the active components of medicinally important plants.

He is in charge of the Analytical Core Facility for the MU Center for Phytonutrient and Phytochemical Studies (MUCPPS) and is part of the research group that makes up the Fusarium/Poultry Research Laboratory at the University of Missouri.

Teaching:
Veterinary Analytical Toxicology Lectures

Selected Publications:

Thomas AL, Chen YC, Rottinghaus GE, Malone AM, Byers PL, Applequist WL, and Finn CE. Occurrence of rutin and chlorogenic acid in elderberry leaf, flower, and stem in response to genotype, environment, and season. Acta Horticulturae 756:197-206, 2008.

Peterson CA, Kubas KL, Hartman SJ, Rottinghaus GE, Taylor JA, and Welshons WV. Lack of skeletal effect of soy isoflavones in intact growing, female rats may be explained by constant serum estrogenic activity despite reduced serum estradiol. Annals of Nutrition and Metabolism 52:48-57, 2008.

Sauter ER, Qin W, Schlatter L, Hewett JE, Ruhlen R, Rottinghaus GE, and Chen YC. Celecoxib concentration predicts decrease in prostaglandin E2 concentrations in both nipple asparate fluid and serum from high risk women. BMC Cancer 8:49, 2008.

Settivari RS, Evans TJ, Rucker E, Rottinghaus GE, and Spiers DE. Effect of ergot alkaloids associated with fescue toxicosis on hepatic cytochrome P450 and antioxidant proteins. Toxicology and Applied Pharmacology 227 (3):347-356, 2008.

Sitaraman D, Zars M, Laferriere H, Chen YC, Sable-Smith A, Rottinghaus GE, and Zars T. Both serotonin and dopamine are necessary for place memory in Drosophila. Proc Natl Acad Sci USA 105(14):5579-5584, 2008.

Settivari RS, Evans TJ, Eichen PA, Rottinghaus GE, and Spiers DE. Short-and long-term responses to fescue toxicosis at different ambient temperatures. J Thermal Biology 33:213-222, 2008.

Sharma D, Asrani RK, Ledoux DR, Jindal N. Rottinghaus GE, Bermudez AJ, and Gupta VK. Individual and combined effects of fumonisin B1 and moniliformin toxicity on clinicopathological and cell mediated immune response in Japanese quail. Poultry Sci 87:1039-1051, 2008.

Gowda NKS, Ledoux DR, Rottinghaus GE, Bermudez AJ, and Chen YC. Efficacy of turmeric (Curcuma longa) and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks. Poultry Science 87:1125-1130, 2008.

Applequist WL, Johnson H, and Rottinghaus GE. (+) catechin and (-)-epicatechin, and gallic acid content of seeds of hybrid grapes hardy in Missouri. American J Enology and Viticulture 59(1):98-102, 2008.

Gupta S, Jindal N, Khokhar RS, Asrani RK, Ledoux DR, and Rottinghaus GE. Individual and combined effects of ochratoxin A and Salmonella enteric serovar Gallinarum infection on pathological changes in broiler chickens. Poultry Science 37(3):265-272, 2008.

Dakovic A, Matijasevic S, Rottinghaus GE, Ledoux DR, Butkeraitis P, and Sekulic Z. Aflatoxin B1 adsorption by natural and copper modified montmorillonite. Colloids and Surfaces B: Biointerfaces 66:20-25, 2008.

Qin W, Zhu W, Hewett JE, Rottinghaus GE, Chen YC, Mannello F, Flynn JT, Kliethermes B, and Sauter ER. uPA is upregulated by high dose celecoxib in women at increased risk of developing breast cancer. BMC Cancer 8:298, 2008.

Stewart, Jr. RL, Scaglia G, Abaye OA, Swecker, Jr. WS, RottinghausGE, Boland HT, McCann M, and Fontenot JP. Estimation of forage intake by steers grazing three fescue types and determination of alkaloids in ruminal fluid and forage. Professional Animal Scientist 24:578-587, 2008.

Peterson CA, Schnell J, Kubas KL, and Rottinghaus GE. Effects of soy isoflavone consumption on bone structure and milk mineral concentration in a rat model of lactation-associated bone loss. European J Nutrition, 48(2):360-371, 2009.

Yarru LP, Settivari RS, Antoniou E, Ledoux DR, and Rottinghaus GE. Toxicological and gene expression analysis of the impact of aflatoxin B1 on hepatic function of male broiler chicks. Poultry Science 88:360-371, 2009.

Looper ML, Rorie RW, Person CN, Lester TD, Hallford DM, Aiken GE, Roberts CA, Rottinghaus GE, and Rosenkrans, CF, Jr. Influence of toxic endophyte-infected fescue on sperm characteristics and endocrine factors of yearling Brahman-influenced bulls. J Animal Science 87:1184-1191, 2009.

Qin W, Zhu W, Shi H, Hewett JE, Ruhlen RL, MacDonald RS, Rottinghaus GE, Chen YC, Sauter ER. Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women. Nutrition and Cancer 61(2):238-244, 2009.

Bozynski CC, Evans TJ, Kim DY, Johnson G, Hughes-Hanks JM, Mitchell WJ, Rottinghaus GE, Perry J, and Middleton JR. Copper toxicosis with hemolysis and hemoglobinuric nephrosis in three adult Boer goats. J Vet Diagn Invest 21(3): 395-400, 2009.

Roberts C, Kallenbach R, Hill N, Rottinghaus GE, and Evans TJ. Ergot alkaloid concentrations in tall fescue hay during production and storage. Crop Science, 49:1496-1502, 2009.

Kutz R, Sampson J, Pompeu LB, Ledoux DR, Spain J, Vazquez-Anon M, and Rottinghaus GE. Efficacy of Solis, Novasil Plus, and MTB-100 to reduce aflatoxin M1 levels in milk of early to mid lactation dairy cows fed aflatoxin B1. J Dairy Science 92:3959-3963, 2009.

Gowda NKS, Ledoux DR, Rottinghaus GE, Bermudez AJ, and Chen YC. Antioxidant efficacy of curcuminoids from turmeric (Curcuma longa) powder in broiler chicks fed diets containing aflatoxin1. British Journal of Nutrition 102:1629-1634, 2009.

Settivari RS, Evans TJ, Yarru LP, Eichen PA, Sutovsky P, Rottinghaus GE, Antoniou E, and Spiers DE. Effects of short-term heat stress on endophytic ergot alkaloid-induced alterations in rat hepatic gene expression. J Animal Sci 87(8):3142-3155, 2009.

Yarru LP, Settivari RS, Gowda NKS, Rottinghaus GE, Antoniou E, and Ledoux DR. Effects of turmeric (Curcuma longa), containing a known level of curcumin, on the expression of hepatic genes associated with biotransformation, antioxidant, and immune systems in broiler chicks. Poultry Science 88:2620-2627, 2009.

Buton A, Chen YC, Rottinghaus GE, and McMullen MD. Genetic variation at bx1 controls DIMBOA content in maize. Theor Appl Genet DOI: 10.1007/s00122-009-1192-1, 2009.

Tessari ENC, Kobashigawa E, Cardoso ALSP, Ledoux DR, Rottinghaus GE, and Oliveira CAF. Effects of aflatoxin B1 and fumonisin B1 on blood biochemical parameters in broilers. Toxins doi:3390/toxins 10x000x, 2009.

Dakovic A, Sekulic Z, Rottinghaus GE, Stojanovic A, Milicevic S, and Kragovic M. T-2 toxin adsorption by hectorite. J Serbian Chemical Soc 74(11):1283-1292, 2009.

 

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