Building Address: D105 VMDL
Phone Number: (573) 882-6811
VMDL Website: http://vmdl.missouri.edu/
Veterinary Diagnostics: I am a board certified veterinary microbiologist with diverse experience in the pathogenesis, diagnosis, and treatment of infectious diseases of domestic and wild animals. Currently, I serve as the Director of Veterinary Medical Diagnostic Laboratory (VMDL) at the University of Missouri. The VMDL is an all species, full service veterinary medical diagnostic laboratory accredited by the American Association of Veterinary Laboratory Diagnosticians (AAVLD). The VMDL is a member of the National Animal Health Laboratory Network (NALHN) and a Tier I member of the Food and Drug Administration (FDA) Veterinary Laboratory Investigation and Response Network (Vet-LRN). The VMDL offers unique opportunities for students, residents, or trainees to gain hands-on experience in the following areas: anatomical pathology, clinical pathology, clinical microbiology, clinical serology, clinical virology, histology and immunohistochemistry, molecular diagnostics, and toxicology.
Research Emphasis: Antimicrobial Resistance, Bacterial Pathogenesis, Emerging & Zoonotic Diseases, Molecular Diagnostics
Non-typhoidal salmonellosis is the second most common cause of food-borne illness associated with bacteria, viruses, and parasites in the US. Each year more than 1.4 million cases with approximately 600 deaths are reported. Salmonella enterica serovar Enteritidis (SE) and Typhimurium are major etiologic agents of non-typhoid salmonellosis in the United States. SE persistently and silently colonizes the intestinal and reproductive tract of laying hens, resulting in contaminated poultry products. The consumption of contaminated food and water has been identified as a significant risk factor for human salmonellosis.
The research in my laboratory is focused on the pathogenesis and diagnosis of Salmonella infection in different host species. Currently, there are four lines of research in my laboratory, including 1) characterizing SE virulence genes that contribute to persistent colonization, 2) characterizing host antimicrobial peptides, 3) surveillance of bacterial antimicrobial resistance, 4) developing PCR-based assays and Micro-electromechanical systems (MEMS)-based biosensing technology for rapid detection of bacterial pathogens in clinical and food samples.
- J. A. McKelvey, M. Yang, L. Jiang, and S. Zhang. Salmonella enterica serovar Enteritidis antimicrobial peptide resistance genes aid in innate immunity defense, fecal shedding, and egg deposition. Infection & Immunity. Sep. 29. 2014.
- X. Zhang, Z. Yu, S. Zhang, K. He. Immunization with H7-HCP-Tir-Intimin significantly reduces colonization and shedding of Escherichia coli O157:H7 in goats. PLoS One. 9(3): e91632, 2014.
- H. Su, J. McKelvey, D. Rollins, M. Zhang, D. Brightsmith, J. Derr, S. Zhang. Cultivable Bacterial Microbiota of Northern Bobwhite (Colinus virginianus): A New Reservoir of Antimicrobial Resistance? Plose One 9(6): e99826, 2014.
- L. Zhao, M. Zhang, and S. Zhang. Expression, purification and comparative in vitro characterization of avian beta-defensin-2, -6, and -12. Avian Dis. 58(4):541-9. 2014.
- R. L. Winter‡, S. G. Gordon, S. Zhang, C. D. Hariu, M.W. Miller. Mural endocarditis caused by Corynebacterium mustelae in a dog with a ventricular septal defect. JAAHA. In press. J Am Anim Hosp Assoc. 50(5):366-72. 2014. doi: 10.5326/JAAHA-MS-6016.
- T. E. Norman, M. Batista, S. D. Lawhon, S. Zhang, K. R. Kuskie, A. K. Swinford, L. R. Bernstein and N. D. Cohen. In vitro susceptibility of equine-obtained isolates of Corynebacterium pseudotuberculosis to gallium maltolate. JCM. 52(7): 2684-2685, 2014.
- J. Guo, S. Payne, S. Zhang, D. Turner, I. Tizard, and P. Suchodolski. Avian Bornaviruses: Disease diagnosis, isolation, and genotyping. Curr Protoc Microbiol 34:15I.1.1-15I.1.33. 2014. doi: 10.1002/9780471729259.
- J. Hilligas, E. Van Wie, J. Barr, K.E. Russell, A.L. Perry1, B.R. Weeks, S. Zhang. Vertebral Osteomyelitis and Multiple Cutaneous Lesions in a Dog Caused by Nocardia pseudobrasiliensis, a Novel Species in Veterinary Medicine. J Vet Intern Med 28(5):1621-5. 2014. doi: 10.1111/jvim.12419.
- M. Zhang, L. Yan, G. Zhu, M. Holifield, D. Todd, and S. Zhang. 2013. Isolation and characterization of Streptococcus troglodytidis sp. nov., from a foot abscess of a chimpanzee (Pan troglodytes).). Int J Syst Evol Microbiol. 63(Pt 2):449-53.
- O. Sammra, A. Balbutskaya, S. Zhang, M. Hijazin, S. Nagib, C. Läm mler, A. Abdulmawjood, E. Prenger-Berninghoff, M. Kostrzewa, M. Timke. Further characteristics of Arcanobacterium canis, a novel species of genus Arcanobacterium. Vet Microbiol. 167(3-4):619-22, 2013.
- H.L. Kvitko-White‡, A.K. Cook, M.B. Nabity, S. Zhang, S.D. Lawhon. Evaluation of a catalase-based urine test for detection of urinary tract infection in dogs and cats. J Vet Intern Med 27(6): 1379-1384, 2013.
- S. Zhang, W. Corapi, E. Quist‡, S. Griffin, M. Zhang. Aspergillus versicolor, a New Causative Agent of Canine Disseminated AspergillosisJ Clin Microbiol. 50:187-191, 2012.
- M. Z. Zhang and S. Zhang. An efficient DNA extraction method for polymerase chain reaction-based detection of Mycobacterium avium subspecies paratuberculosis in bovine fecal samples. J Vet Diagn Invest. 23:41-48, 2011.
- L. Yan*, S. Zhang, H. Wan, L. W. Pace, F. Wilson, M. Z. Zhang. Combination of reverse transcription real-time polymerase chain reaction and antigen capture enzyme-linked immunosorbent assay for the detection of animals persistently infected with Bovine viral diarrhea virus. J Vet Diagn Invest. 23:16-25, 2011.
- B. Baughman, S. Zhang, L. Jin, L. W. Pace, J. Cooley, L. Yan*, M. Z. Zhang. Diagnosis of deerpox virus infection in a white-tailed deer fawn. J Vet Diagn Invest. 23:965-970, 2011.
- J. Tomlinson, J. Cooley, S. Zhang, M. Johnson. Granulomatous lymphadenitis in a labrador retriever due to Talaromyces helicus. Vet Clin Path. 40(4): 553-557, 2011.
- S. Khare, W. Alali, S. Zhang, D. Hunter, R. Pugh, F. C. Fang, S. J. Libby, and L Garry Adams. Vaccination with attenuated Salmonella enterica Dublin expressing E. coli O157:H7 outer membrane protein Intimin induces transient reduction of fecal shedding of E coli O157:H7 in cattle. BMC Vet Res. 6:35, 2010.